Sunday, 14 October 2012

Mucous not glucose deficiency

I mentioned briefly in my first post on principles of a healthy carnivore diet that mucin is important and which amino acids are needed to ensure proper production, but I didn't go into a lot of detail at the time as to why mucin is important and the full implications of a imbalanced amino acid profile.

I haven't posted on this blog in a long time for various reasons, one of which is that I have been helping my good friend Danny Albers with his facebook page Primal North. Primal North and Mostly Meat Is What I Eat have a very similar view on nutrition, and the two of us have improved each others diets and dietary views through the many conversations I've had with Danny over the last several months. One change I've made is cutting out starches and vegetables, making 'Meat Is Almost All I Eat' as it were, and Danny has started putting gelatin in his coffee.

One topic we discussed was my theory about the truth behind Paul Jaminet's 'glucose deficiency'. Jaminet says that when we was eating a zero carb diet (except he wasn't as he doesn't consider vegetables as calories sources and thus counts what everyone else would call a low-carb diet a zero-carb one), that he experienced several problems including dry eyes, constipation, and a dry cough. Jaminet even claims that people die of starvation because of the dry cough they develop: "A clue is the fact that starving people develop a hacking cough in their final weeks of life. Despite blood glucose levels in the normal range, they cease producing mucus and their airways become dry and irritated." This is contrary to the well known general cause of death in starvation, which is heart failure. Everyone knows during prolonged starvation your muscle start to waste away, but it's not just your biceps that get eaten, eventually your body starts using the heart (which is a muscle) as well, ultimately the heart becomes so weakened it can't pump blood and you die of heart failure.

Danny rightly points out that a dry cough may be a cause of death in starving people due to a lack of mucous, but that that is in starving people, nutritional ketosis and starvation are vastly different. Yes, both have increased blood ketones and a lack of dietary carbohydrates but that is where the similarities end. A low/zero-carb diet producing nutritional ketosis includes protein, plenty of fat for fuel, vitamins, and minerals. We don't know if this 'dry cough = death' thing is from lack of carbohydrates, protein in general or specific amino acid(s), calories, a vitamin, or mineral. Unless properly tested we may never know, but it's unlikely such studies will ever occur in humans due the the 'death' factor, and animal testing may not be applicable.

Jaminet's answer, which is has stuck heavily too even to the point of declaring ketogenic diets outright dangerous, is lack of carbohydrates. But he even posts this picture showing the glycogen is fully depleted after just 3 days of fasting/starvation. If a lack of carbohydrates where the cause, then one would expect the problems to occur much much sooner, not the final few days of life.

My theory, which I'm fully stating that I do not know to be true but from talking with other people and seeing the difference after they add gelatin to their diet (which is the exact same level of evidence Jaminet has for his 'glucose deficiency' theory, except he states it as outright truth not as a theory, which it is), is that is it not a glucose deficiency but a mucous (or more specifically mucin) deficiency caused by an imbalanced amino acid profile.

Mucin is a glycoprotein, this means it's part carbohydrate ('glyco' as in glucose), and part protein. Jaminet has focused in on the 'glyco' part, I have explored the 'protein' side of things. In my research I discovered that mucin production is highly sensitive the the availability of certain amino acids: cysteine, proline, serine, and threonine. Cysteine is an essential sulphur-containing amino acid, which meat and eggs are very rich in. Proline is a conditionally essential amino acid, which along with glycine makes up most of gelatin. Serine is a non-essential amino acid which is made from glycine. Glycine and proline are very low in meat, fish, organs, dairy, eggs, and vegetarian protein sources; the only decent source is gelatin. Threonine is an essential amino acid, and meat, fish, eggs, and dairy are good sources. On a diet where the protein only comes from meat, fish, eggs, or dairy, there is plenty of cysteine and threonine, but very little glycine and proline.

Gelatin can be found in many foods, not just powdered gelatine like for making jelly/jell-o, in fact about half (update: 25-35%) of the protein in an animal is made of gelatin. But if this is the case, why is meat low in gelatin? Muscle meat certainly is, the gelatin is found in the 'odd bits' as Danny calls them: skin, feet/hooves, cartilage, heads, hair, and nails/claws. Traditionally the whole animal was eaten, not just the meat and even organs, but the 'odd bits' where simmered for days covered with water with some acid such as vinegar or lemon juice added. The acid would breakdown the 'odd bits' and a delicious gelatin-rich broth/stock was created which would turn into a solid jelly/jell-o if put in a fridge. This broth would then be used as the base for soups, stews, sauces, and even drunk straight in times of illness when no other food would stay down. Gelatin is a truly wonderful food, and incredibly healing to the gut as enterocytes (intestine cells that do the absorbing) can feed off glycine directly. Gelatin is also very good for joints, as cartilage is made from gelatin, and in the same way it helps keep the skin smooth and wrinkle-free (could abandoning gelatin-rich broth be the reason for all these 'anti-ageing' creams?), and help your hair grow thick and shiny and your nails strong.

The paleo community has made many improvements over the years, from lean meat to fatty, and more decently the addition of organs such as liver, but is still lacking in the encouragement of making and using home-made gelatinous broth. This is one thing Ray Peat gets right (see here), but both Danny and I very much disagree with his promotion of eating large amounts of refined white sugar.

Please note: all store-bought 'broth', 'stock', and bouillon cubes are nothing like real home-made broth, they are made from flours, salt, MSG, and many other chemicals. There is no substitute for the real home-made stuff.

I also encouragement the inclusion of egg shells along with bones and gelatin sources in broth, as egg shells help boost the calcium content and the membrane includes chondroitin which is also very good for joints.

Lastly, I will point out that there are many factors other than a proper amino acid profile in maintaining moist mucous membranes, such as vitamin A (retinol), saturated fats, choline, cholesterol, and many others. Retinol (true vitamin A) deficiency results in mucous-secreting cells mutating into keratin-secreting cells which results in lesions being formed, in the eye this leads to xerophthalmia and eventually keratomalacia and blindness. Saturated fats are need to form surfactants in the lungs which reduce surface tension so gas exchange can happen, the most common surfactant is dipalmitoylphosphatidylcholine, made from choline and two palmitic acids (a saturated fat); cholesterol also makes up part of the surfactants.

You'll notice that all the nutrients listed for maintaining mucous membranes are only found in animal foods (there is some palmitic acid in palm oil though) so it is highly unlikely that a problem involving mucous membranes results from a lack of plant foods in your diet. Much more likely is that it results from an imbalanced intake of certain animal foods over others, that is too much meat and not enough gelatin.


  1. Thanks for this post. The glucose-deficiency 'theory' has always bothered me, as it has no clinical evidence and seems more like a way to push a different diet plan. I would actually rather rename it to glucose deficiency hypothesis, since it is currently only conjecture. A theory would have been supported with actual testing - not anecdotes.

    This is also good timing because I just ordered a big sack of powdered gelatin to start supplementing. How do you feel about this method over making bone broth? I've made it before, but the powder seems like an easier/cheaper way to get a known dose.

    1. Powdered is fine. Personally I don't like it though. If using powdered gelatin, it's still important to make plain bone broth for the minerals.

  2. In addition, gelatin provides good benefit in our health not only with what are those being mentioned above. Gelatin made broth helps the body use protein in a more efficient way. It has been used effectively to treat digestive disorders. In addition to treating disease and illness, seek an internal medicine for far better advice.

    1. I'm aware of both these uses/properties of gelatin. Gelatin treats digestive disorders are enterocytes can feed off glycine directly, as mentioned above.

  3. Good Post. As to not thread-hijack on IPMG - Paragraph 7 makes it sound like it is a lack of Proline, to some degree, that leads to dry membranes, especially with this bit "Glycine and proline are very low in meat, fish, organs, DAIRY [emphasis mine]." I only mention it because, as I said on IPMG, dairy would seem to be a good source at about 12% Proline. Though I'm not sure on bio-availability.

    I agree with your conclusions 100% however, that with enough gelatin, and not over eating the lean, your gut can be quite happy with almost no carb.

    1. Milk protein is ~9% proline, beef ~6%, gelatin ~14.4%. So milk is a richer source of proline per protein than beef but beef is much higher in total protein than milk. Although proline is important, the main reason to include gelatin is for the glycine, but the secondary boost in proline is still very welcomed, sorry if the wording was a little confusing there. Proline is conditionally essential though so getting more in your diet does help. Milk does contain things such as lactose and also damaged proteins if pasteurised which can make it a worse source from protein compared to meat.

      I would argue that for many replacing starch/carbs with gelatin would actually make the gut a lot happier.

  4. Sorry some of these replies took so long. For some reason on my computer I can't comment on my blog, I can log into the admin panel but not into the blog itself to comment. Using my brother's computer to do this. Technology is annoying.

  5. I have a couple of questions.

    What if one were to roast a whole chicken, but just without skin (to minimise PUFA content), and then consume everything including the stock in portions with stuff like butter, cuts of beef or lamb along with ox liver and eggs? I assume that this would provide adequate gelatine. What do you think?


    1. Use the whole chicken with the skin, then after the broth is made, put in the fridge, all the fat floats to the top and can be easily skimmed off even if not fully solid due to the PUFA content. Add butter or whatever other healthy fat to the broth as you drink it. The rest (beef/lamb, eggs, and liver) is fine.

  6. Hello, really good article. I have severe gut issues so I am drawn to low carb, but every time I do it I get alot dry phlemby mucus stuck in my throat that will not go away. Then it gives me horrible breath, so then I go for sushi rice to get rid of this awful thing in my throat. Would gelatin help in this area? And if so how much in grams per day would you recommend? Thanks

    1. As per my question above about quantity, I mean if I use powdered gelatin. How much would I need to offset the mucus problem? Thanks again

    2. Ideal gelatin would be 15-30% of total protein intake, a sachet of powdered gelatin is usually about 7g.

  7. For 36 eggs:
    Aspartic acid23937mg
    Glutamic acid33111mg

    Eggs are a good source according to this site:

    Who is wrong, you or the site?

    1. This comment has been removed by the author.

  8. Forgot to thank you. This was the missing link in my research, I couldn't understand why I would be binging on carbs after a week. Well, here it is! Thank you.

  9. Hello

    please do you have a list of all factors causing mucous deficiency ? Any possible problem ( even rare ones ) can be it. (except: glycine, vitamin A, choline, cholesterol, glucose, saturated fats)

    Thanks so much

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  11. Interesting post thank you.